County emergency dispatchers said the crash occurred shortly before 2 p.m. at Racetrack and Wilson Fox roads in Youngwood.
Youngwood Fire Chief Lloyd Crago said an SUV was driving north on Racetrack Road when it left the roadway and struck a tree. The vehicle rolled over, came back onto the roadway and collided with a van that was going southbound.
The coroner’s office pronounced the driver of the SUV, 88-year-old Elizabeth Anderson, of Hempfield Township, dead at the scene.
State police in Greensburg and the coroner are investigating.