Ambridge police said the incident occurred in the 900 block of Maplewood Avenue around 1:30 p.m.
Inside the home, police found the children dead. They were identified as 16-year-old Jeffrey Bright and 22-year-old Jasmine Cannady.
The mother, 48-year-old Krisinda Bright, was arrested for the shooting, according to Interim Chief John Deluca. She was the one who actually called 911.